N-acetyl Cysteine Alleviates Cytotoxicity of Bone Substitute

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N-acetyl cysteine alleviates cytotoxicity of bone substitute.

Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20%...

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ژورنال

عنوان ژورنال: Journal of Dental Research

سال: 2010

ISSN: 0022-0345,1544-0591

DOI: 10.1177/0022034510363243